Direct comparison
Tirzepatid vs Mazdutid
Class
GLP-1 analog
GLP-1 analog
Mechanism
Tirzepatide is a dual agonist at GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 receptors.
Mazdutide is a dual agonist at GLP-1 and glucagon receptors, derived from oxyntomodulin (OXM).
Studied effects
Metabolism
Metabolism
Evidence level
clinically established
early clinical studies
Legal status (DE)
prescription-only
not approved
WADA-listed
No
No
Half-life
~5 days
~6 days (once weekly)
Studies cited
3
2
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