Direct comparison
Semaglutid vs Tirzepatid
Class
GLP-1 analog
GLP-1 analog
Mechanism
Semaglutide is a synthetic analog of the body's own incretin hormone GLP-1 (glucagon-like peptide-1).
Tirzepatide is a dual agonist at GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 receptors.
Studied effects
Metabolism
Metabolism
Evidence level
clinically established
clinically established
Legal status (DE)
prescription-only
prescription-only
WADA-listed
No
No
Half-life
~7 days
~5 days
Studies cited
3
3
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