Tirzepatid
In a large trial, participants lost about 20 % of their body weight on average.
What it does in the body
Findings, each with its evidence level — animal data kept visibly apart from what's unproven in humans.
In a large trial, participants lost about 20 % of their body weight on average.
PROVEN IN HUMANSActs on two gut-hormone signals at once to boost insulin release — proven in type-2 diabetes.
PROVEN IN HUMANSIn a head-to-head trial it lowered blood sugar and weight more than semaglutide.
PROVEN IN HUMANSAlso acts directly on fat tissue (as described in research).
MECHANISM ONLYMechanism of action
What Tirzepatid does in the body — step by step.
Tirzepatide is a dual agonist at GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 receptors.
It is a synthetic 39-amino-acid peptide with a C20 fatty-acid side chain that enables binding to albumin and thus a half-life of about 5 days.
The simultaneous activation of both incretin receptors is intended to produce synergistic effects on insulin secretion, glucagon inhibition and food intake compared with pure GLP-1 agonists.
Research status
How far along is the evidence?
Known risks
Without human data, safety statements are limited. What is known:
Cited studies
Chronological — links lead to the source.
Frequently asked questions
What is Tirzepatid?+
Tirzepatide is a dual agonist at GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 receptors.
What type of peptide is Tirzepatid?+
Tirzepatid belongs to the GLP-1 analog class.
What is Tirzepatid used for?+
In research, Tirzepatid has primarily been investigated in the context of: Metabolism. These are research findings (evidence: clinically established), not proven benefits in humans and not a usage recommendation.
Is Tirzepatid legal in Germany?+
Tirzepatid is prescription-only in Germany and may only be obtained with a medical prescription.
Is Tirzepatid FDA-approved / legal in the US?+
Tirzepatid is a prescription, FDA-approved medication in the US.
Is Tirzepatid legal in Canada?+
Tirzepatid is a prescription medication authorized by Health Canada.
Where can I buy Tirzepatid?+
Peptica sells nothing and names no sources. Tirzepatid is "prescription-only" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.
What is the dosage of Tirzepatid?+
Peptica publishes no dosing. Tirzepatid is a prescription medicine — any dosing is determined individually by a physician. This is not medical advice.
Is Tirzepatid banned in sport (WADA)?+
Tirzepatid is currently not on the WADA Prohibited List.
What are the known risks of Tirzepatid?+
Documented risks include: Gastrointestinal side effects: nausea, vomiting, diarrhoea, constipation (the most common side effects in studies); Hypoglycaemia risk in combination with insulin or sulfonylureas. This is not a complete safety assessment and not medical advice — see the risks section for the full list.
How well researched is Tirzepatid?+
The evidence is classified as “clinically established”. 3 studies are cited on this page.
What is the molecular weight of Tirzepatid?+
Tirzepatid has a molar mass of about 4813.45 Da, with a plasma half-life of ~5 days.
Which peptides are related to Tirzepatid?+
Closely related entries: Retatrutid, Semaglutid. A direct side-by-side comparison is available via the compare function.
Dossier
Legal · Structure · Sources.
Tirzepatide is approved in the EU as Mounjaro — for type 2 diabetes (2022) and for obesity (2024). In the USA it is additionally approved as Zepbound for obesity. Obtaining it without a medical prescription is illegal in Germany under § 48 AMG. Not on the WADA Prohibited List; monitoring status currently not specified.
Legal status varies by country and can change. This is not legal advice.
Methodology: Peptica compiles publicly available studies and regulatory information and assigns each statement an evidence level. Not medical advice. No warranty.