Survodutid · DOSSIER

Survodutid

Survodutide · BI 456906
LEGAL DE · NOT APPROVEDEVIDENCE · EARLY CLINICAL STUDIES2 STUDIES
FIG.01 — SIGNAL CHAIN
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Mechanism of action

What Survodutid does in the body — step by step.

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Survodutide is a dual agonist at glucagon and GLP-1 receptors.

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The GLP-1 component promotes glucose-dependent insulin secretion and satiety, while the glucagon component is intended to increase energy expenditure and hepatic fat metabolism.

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The aim of this combination is weight reduction beyond that of pure GLP-1 agonists, together with a favourable effect on the liver.

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Research status

How far along is the evidence?

PRECLINICALEARLY CLINICAL STUDIESCLINICALLY ESTABLISHED
Survodutide is in advanced clinical development (Boehringer Ingelheim / Zealand Pharma).
Survodutide is in advanced clinical development (Boehringer Ingelheim / Zealand Pharma).
A Phase II study (2024) in obesity documented substantial weight reductions versus placebo.
A further Phase II study investigated survodutide in MASH (metabolic dysfunction-associated steatohepatitis) and liver fibrosis, with positive signals on liver histology.
Phase III studies are ongoing; there is no market approval yet.
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Known risks

Without human data, safety statements are limited. What is known:

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Safety profile not conclusively established — no completed Phase III data
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Gastrointestinal side effects (nausea, vomiting, diarrhoea) common
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Glucagon agonism can affect heart rate and blood sugar
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Gallbladder complications possible with rapid weight loss
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No long-term safety data available
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Cited studies

Chronological — links lead to the source.

2024
Glucagon and GLP-1 receptor dual agonist survodutide for obesity: a randomised, double-blind, placebo-controlled, dose-finding phase 2 trial
PubMed 38330987 →
2024
A Phase 2 Randomized Trial of Survodutide in MASH and Fibrosis
PubMed 38847460 →
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Frequently asked questions

What is Survodutid?+

Survodutide is a dual agonist at glucagon and GLP-1 receptors.

What type of peptide is Survodutid?+

Survodutid belongs to the GLP-1 analog class.

What is Survodutid used for?+

In research, Survodutid has primarily been investigated in the context of: Metabolism. These are research findings (evidence: early clinical studies), not proven benefits in humans and not a usage recommendation.

Is Survodutid legal in Germany?+

Survodutid is not approved as a medicine in Germany. Obtaining it outside clinical studies is legally problematic.

Is Survodutid FDA-approved / legal in the US?+

No. Survodutid is not FDA-approved as a drug in the US; it is mostly sold as a research chemical and not for human consumption.

Is Survodutid legal in Canada?+

No. Survodutid is not authorized by Health Canada and not intended for human consumption.

Where can I buy Survodutid?+

Peptica sells nothing and names no sources. Survodutid is "not approved" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.

What is the dosage of Survodutid?+

Peptica publishes no dosing. There are no approved dosing guidelines for Survodutid; figures circulating online stem from animal studies or anecdote, not from validated human protocols. This is not medical advice.

Is Survodutid banned in sport (WADA)?+

Survodutid is currently not on the WADA Prohibited List.

What are the known risks of Survodutid?+

Documented risks include: Safety profile not conclusively established — no completed Phase III data; Gastrointestinal side effects (nausea, vomiting, diarrhoea) common. This is not a complete safety assessment and not medical advice — see the risks section for the full list.

How well researched is Survodutid?+

The evidence is classified as “early clinical studies”. 2 studies are cited on this page.

What is the molecular weight of Survodutid?+

Survodutid has a molar mass of about 4232 Da, with a plasma half-life of ~6–7 days (once weekly).

Which peptides are related to Survodutid?+

Closely related entries: Retatrutid, Tirzepatid, Semaglutid, Mazdutid. A direct side-by-side comparison is available via the compare function.

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Dossier

Legal · Structure · Sources.

LEGAL STATUS BY REGION
Germanynot approved

Survodutide does not yet have market approval and is in Phase III studies. Obtaining it as a research chemical outside clinical studies is illegal and carries considerable safety risks.

Legal status varies by country and can change. This is not legal advice.

SOURCES & EXTERNAL DATABASES

Methodology: Peptica compiles publicly available studies and regulatory information and assigns each statement an evidence level. Not medical advice. No warranty.

RELATED PEPTIDES & FURTHER READING
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Community notes

Note: These posts are user opinions and not medical advice. Posts containing dosages, therapeutic claims or purchase recommendations are removed. All entries are manually reviewed before publication.
This page is intended solely for factual, scientifically oriented information. No medical advice · no dosage or usage recommendations · no claims of efficacy · no substitute for medical consultation. Peptica sells no substances. Partner links are marked as advertising; Peptica may earn a commission. © 2026 Peptica · Issue 01