Direct comparison
Melanotan I vs Melanotan II
Class
Melanocortin
Melanocortin
Mechanism
Melanotan I is a linear analog of α-melanocyte-stimulating hormone (α-MSH) with increased stability through the Nle4 and D-Phe7 substitutions.
Melanotan II is a synthetic cyclic heptapeptide and a non-selective agonist at melanocortin receptors (MC1R, MC3R, MC4R, MC5R).
Studied effects
Skin & hair
Libido, Skin & hair
Evidence level
clinically established
preclinical
Legal status (DE)
prescription-only
not approved
WADA-listed
No
Yes
Half-life
~30 minutes (peptide)
Limited data; the plasma half-life is reported to be around one hour (sources range from ~30 minutes to a few hours).
Studies cited
2
2
Sourcing & partnersAd
europeptidesPEPTICA
europeptides
Visit partner →unyxpeptides
unyxpeptides
Visit partner →clearpeptidesPeptica
clearpeptides
Visit partner →Partner / affiliate links — Peptica may earn a commission. No endorsement; not medical advice. Peptica sells no substances.
Related comparisons
Important notice
This site is intended solely for factual, scientifically oriented information about peptides. It does not constitute medical advice, does not replace a consultation with a doctor and contains no recommendations for use in humans. Peptica sells no substances and names no sources for unapproved substances.