Somatropin (HGH) · DOSSIER

Somatropin (HGH)

Somatropin · HGH · Peptide · 191 AS
LEGAL DE · PRESCRIPTION-ONLYEVIDENCE · CLINICALLY ESTABLISHED2 STUDIESWADA · S2
FIG.01 — SIGNAL CHAIN
02

Mechanism of action

What Somatropin (HGH) does in the body — step by step.

01

Somatropin is recombinant human growth hormone (hGH), a 191-amino-acid protein that matches the body's own pituitary growth hormone in structure and action.

02

It binds to the growth hormone receptor and mediates its effects partly directly and partly via the release of IGF-1, predominantly in the liver.

03

Described effects include longitudinal growth (in childhood), protein synthesis, lipolysis and carbohydrate metabolism.

03

Research status

How far along is the evidence?

PRECLINICALEARLY CLINICAL STUDIESCLINICALLY ESTABLISHED
Somatropin is an established, approved medicine with decades of clinical experience.
Somatropin is an established, approved medicine with decades of clinical experience.
Approved indications include growth hormone deficiency in children and adults and certain genetic syndromes.
Reviews address the diagnosis of growth hormone deficiency and the benefits and risks of replacement therapy in adults.
Use for anti-aging or performance purposes is not approved and not scientifically supported.
04

Known risks

Without human data, safety statements are limited. What is known:

01
Fluid retention, peripheral oedema, carpal tunnel syndrome
02
Arthralgia and myalgia
03
Insulin resistance and increased diabetes risk
04
Theoretical risk of promoting growth of pre-existing tumours
05
Acromegaly-like changes with long-term excess
06
Legal risk: WADA ban, ADBG/DmMV relevance
07
Product quality cannot be verified from unapproved sources
05

Cited studies

Chronological — links lead to the source.

2021
Growth hormone deficiency and replacement therapy in adults: Impact on survival
PubMed 33068227 →
2023
Diagnosis and testing for growth hormone deficiency across the ages: a global view of the accuracy, caveats, and cut-offs for diagnosis
PubMed 37052176 →
06

Frequently asked questions

What is Somatropin (HGH)?+

Somatropin is recombinant human growth hormone (hGH), a 191-amino-acid protein that matches the body's own pituitary growth hormone in structure and action.

What type of peptide is Somatropin (HGH)?+

Somatropin (HGH) belongs to the Growth hormone class.

What is Somatropin (HGH) used for?+

In research, Somatropin (HGH) has primarily been investigated in the context of: Muscle growth, Metabolism, Anti-aging. These are research findings (evidence: clinically established), not proven benefits in humans and not a usage recommendation.

Is Somatropin (HGH) legal in Germany?+

Somatropin (HGH) is prescription-only in Germany and may only be obtained with a medical prescription. It is additionally relevant under the German Doping Agent Quantity Ordinance (DmMV).

Is Somatropin (HGH) FDA-approved / legal in the US?+

Somatropin (HGH) is a prescription, FDA-approved medication in the US.

Is Somatropin (HGH) legal in Canada?+

Somatropin (HGH) is a prescription medication authorized by Health Canada.

Where can I buy Somatropin (HGH)?+

Peptica sells nothing and names no sources. Somatropin (HGH) is "prescription-only" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.

What is the dosage of Somatropin (HGH)?+

Peptica publishes no dosing. Somatropin (HGH) is a prescription medicine — any dosing is determined individually by a physician. This is not medical advice.

Is Somatropin (HGH) banned in sport (WADA)?+

Yes. Somatropin (HGH) is on the WADA Prohibited List and is therefore banned in competitive sport.

What are the known risks of Somatropin (HGH)?+

Documented risks include: Fluid retention, peripheral oedema, carpal tunnel syndrome; Arthralgia and myalgia. This is not a complete safety assessment and not medical advice — see the risks section for the full list.

How well researched is Somatropin (HGH)?+

The evidence is classified as “clinically established”. 2 studies are cited on this page.

What is the molecular weight of Somatropin (HGH)?+

Somatropin (HGH) has a molar mass of about 22124 Da, with a plasma half-life of ~3–4 hours (s.c.).

Which peptides are related to Somatropin (HGH)?+

Closely related entries: CJC-1295, Tesamorelin, IGF-1, Sermorelin. A direct side-by-side comparison is available via the compare function.

07

Dossier

Legal · Structure · Sources.

LEGAL STATUS BY REGION
Germanyprescription-only

Somatropin is an approved, prescription-only medicine. As a growth hormone it is on the WADA Prohibited List (S2) and falls under the German Anti-Doping Act (ADBG) and the German Doping Agent Quantity Ordinance (DmMV). Possession of more than a minor quantity may be punishable; obtaining it without a prescription is illegal.

Legal status varies by country and can change. This is not legal advice.

SOURCES & EXTERNAL DATABASES

Methodology: Peptica compiles publicly available studies and regulatory information and assigns each statement an evidence level. Not medical advice. No warranty.

RELATED PEPTIDES & FURTHER READING
08

Community notes

Note: These posts are user opinions and not medical advice. Posts containing dosages, therapeutic claims or purchase recommendations are removed. All entries are manually reviewed before publication.
This page is intended solely for factual, scientifically oriented information. No medical advice · no dosage or usage recommendations · no claims of efficacy · no substitute for medical consultation. Peptica sells no substances. Partner links are marked as advertising; Peptica may earn a commission. © 2026 Peptica · Issue 01