Tesamorelin
In large trials, deep belly fat shrank markedly in an HIV-related fat-distribution disorder.
What it does in the body
Findings, each with its evidence level — animal data kept visibly apart from what's unproven in humans.
In large trials, deep belly fat shrank markedly in an HIV-related fat-distribution disorder.
PROVEN IN HUMANSBoosts the body's own growth hormone while keeping its natural self-regulation intact.
MECHANISM ONLYIt's only approved for that HIV disorder — no solid data for muscle-building or anti-ageing.
UNPROVEN IN HUMANSMechanism of action
What Tesamorelin does in the body — step by step.
Tesamorelin is a synthetic analog of human GHRH (growth hormone-releasing hormone), consisting of the complete GHRH(1-44) peptide with a trans-3-hexenoic acid modification at the N-terminus.
This modification increases stability against enzymatic degradation by dipeptidyl peptidase IV (DPP-IV).
Tesamorelin stimulates pituitary GH secretion in a physiological, pulsatile manner, as it preserves the endogenous feedback regulation via IGF-1 and somatostatin.
Research status
How far along is the evidence?
Known risks
Without human data, safety statements are limited. What is known:
Cited studies
Chronological — links lead to the source.
Frequently asked questions
What is Tesamorelin?+
Tesamorelin is a synthetic analog of human GHRH (growth hormone-releasing hormone), consisting of the complete GHRH(1-44) peptide with a trans-3-hexenoic acid modification at the N-terminus.
What type of peptide is Tesamorelin?+
Tesamorelin belongs to the GHRH analog class.
What is Tesamorelin used for?+
In research, Tesamorelin has primarily been investigated in the context of: Muscle growth, Metabolism. These are research findings (evidence: clinically established), not proven benefits in humans and not a usage recommendation.
Is Tesamorelin legal in Germany?+
Tesamorelin is not approved as a medicine in Germany. Obtaining it outside clinical studies is legally problematic. It is additionally relevant under the German Doping Agent Quantity Ordinance (DmMV).
Is Tesamorelin FDA-approved / legal in the US?+
Tesamorelin is a prescription, FDA-approved medication in the US.
Is Tesamorelin legal in Canada?+
Tesamorelin is a prescription medication authorized by Health Canada.
Where can I buy Tesamorelin?+
Peptica sells nothing and names no sources. Tesamorelin is "not approved" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.
What is the dosage of Tesamorelin?+
Peptica publishes no dosing. There are no approved dosing guidelines for Tesamorelin; figures circulating online stem from animal studies or anecdote, not from validated human protocols. This is not medical advice.
Is Tesamorelin banned in sport (WADA)?+
Yes. Tesamorelin is on the WADA Prohibited List and is therefore banned in competitive sport.
What are the known risks of Tesamorelin?+
Documented risks include: Fluid retention, peripheral oedema (typical GH-class side effect); Arthralgia and myalgia under elevated GH/IGF-1 levels. This is not a complete safety assessment and not medical advice — see the risks section for the full list.
How well researched is Tesamorelin?+
The evidence is classified as “clinically established”. 2 studies are cited on this page.
What is the molecular weight of Tesamorelin?+
Tesamorelin has a molar mass of about 5135.9 Da, with a plasma half-life of ~25–40 minutes.
Which peptides are related to Tesamorelin?+
Closely related entries: CJC-1295, Ipamorelin. A direct side-by-side comparison is available via the compare function.
Dossier
Legal · Structure · Sources.
Tesamorelin is FDA-approved in the USA as Egrifta for HIV-associated lipodystrophy but has no EMA approval for the EU market. As a GHRH analog, it is on the WADA Prohibited List (S2) and falls under the German Anti-Doping Act (ADBG) and the German Doping Agent Quantity Ordinance (DmMV). Possession of more than a minor quantity may be punishable under § 4 ADBG.
Legal status varies by country and can change. This is not legal advice.
Methodology: Peptica compiles publicly available studies and regulatory information and assigns each statement an evidence level. Not medical advice. No warranty.