PE-22-28
Mechanism of action
What PE-22-28 does in the body — step by step.
PE-22-28 is a shortened analog of spadin, an endogenous peptide derived from the propeptide of the sortilin/neurotensin receptor 3.
It inhibits the potassium channel TREK-1, which is involved in mood regulation and depression.
In preclinical models a rapid antidepressant effect and promotion of neurogenesis and synaptogenesis are described.
Research status
How far along is the evidence?
Known risks
Without human data, safety statements are limited. What is known:
Cited studies
Chronological — links lead to the source.
Frequently asked questions
What is PE-22-28?+
PE-22-28 is a shortened analog of spadin, an endogenous peptide derived from the propeptide of the sortilin/neurotensin receptor 3.
What type of peptide is PE-22-28?+
PE-22-28 belongs to the Neuropeptide class.
What is PE-22-28 used for?+
In research, PE-22-28 has primarily been investigated in the context of: Cognition. These are research findings (evidence: preclinical), not proven benefits in humans and not a usage recommendation.
Is PE-22-28 legal in Germany?+
PE-22-28 is not approved as a medicine in Germany. Obtaining it outside clinical studies is legally problematic.
Is PE-22-28 FDA-approved / legal in the US?+
No. PE-22-28 is not FDA-approved as a drug in the US; it is mostly sold as a research chemical and not for human consumption.
Is PE-22-28 legal in Canada?+
No. PE-22-28 is not authorized by Health Canada and not intended for human consumption.
Where can I buy PE-22-28?+
Peptica sells nothing and names no sources. PE-22-28 is "not approved" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.
What is the dosage of PE-22-28?+
Peptica publishes no dosing. There are no approved dosing guidelines for PE-22-28; figures circulating online stem from animal studies or anecdote, not from validated human protocols. This is not medical advice.
Is PE-22-28 banned in sport (WADA)?+
PE-22-28 is currently not on the WADA Prohibited List.
What are the known risks of PE-22-28?+
Documented risks include: No human studies — safety profile entirely unknown; Interference with TREK-1/mood signalling with unclear consequences. This is not a complete safety assessment and not medical advice — see the risks section for the full list.
How well researched is PE-22-28?+
The evidence is classified as “preclinical”. 2 studies are cited on this page.
Which peptides are related to PE-22-28?+
Closely related entries: Semax, Selank. A direct side-by-side comparison is available via the compare function.
Dossier
Legal · Structure · Sources.
PE-22-28 is not approved as a medicine and is solely a preclinical research substance. Not on the WADA Prohibited List. Obtaining it as a research chemical carries considerable quality and safety risks.
Legal status varies by country and can change. This is not legal advice.
Methodology: Peptica compiles publicly available studies and regulatory information and assigns each statement an evidence level. Not medical advice. No warranty.