Structure · schematic
Peptide chain · Neuropeptid
Schematic representation of the amino acid chain — not a chemical structural formula. Each node represents one amino acid.
Research areas*
* Contexts in which the peptide has been scientifically studied — not assured or recommended effects.
Mechanism of action
- P021 is a small, peptidomimetic molecule derived from an active region of ciliary neurotrophic factor (CNTF).
- It is designed to be metabolically stable and able to cross the blood–brain barrier.
- In preclinical models it is credited with promoting neurogenesis and neurotrophic signalling (including BDNF) and inhibiting pathological tau changes.
- It is investigated in the context of Alzheimer's models.
Research status
- P021 has so far been studied exclusively preclinically, mainly in rodent and disease models of Alzheimer's disease.
- Work describes prevention of dendritic and synaptic deficits and of cognitive impairment.
- Controlled human studies do not exist.
- Safety and efficacy in humans are not demonstrated.
Evidence level
Cited studies
Known risks
- 01No human studies — safety profile entirely unknown
- 02Long-term effects on the nervous system unknown
- 03Interactions not characterised
- 04Product quality cannot be verified from unapproved sources
Frequently asked questions
What is P021?
P021 is a small, peptidomimetic molecule derived from an active region of ciliary neurotrophic factor (CNTF).
What type of peptide is P021?
P021 belongs to the Neuropeptide class.
Is P021 legal in Germany?
P021 is not approved as a medicine in Germany. Obtaining it outside clinical studies is legally problematic.
Where can I buy P021?
Peptica sells nothing and names no sources. P021 is "not approved" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.
Is P021 banned in sport (WADA)?
P021 is currently not on the WADA Prohibited List.
What are the known risks of P021?
Documented risks include: No human studies — safety profile entirely unknown; Long-term effects on the nervous system unknown. This is not a complete safety assessment and not medical advice — see the risks section for the full list.
How well researched is P021?
The evidence is classified as “preclinical”. 2 studies are cited on this page.
What is the molecular weight of P021?
P021 has a molar mass of about 578.7 Da.
Which peptides are related to P021?
Closely related entries: Semax, Dihexa. A direct side-by-side comparison is available via the compare function.
Related entries
Legal status
Germany
not approvedAustria
not approvedSwitzerland
not approvedEU
not approvedUSA
not approvedCanada
not approvedLegal status varies by country and can change. This is not legal advice.
Sources & methodology
- 2 peer-reviewed studies cited, linked to PubMed where available.
- Molecular data verified against PubChem and primary literature. PubChem CID 56599151
- Editorial standard: no dosage guidance, no sources, evidence level stated explicitly.
Last editorially reviewed: 30 May 2026
Legal assessment
P021 is not approved as a medicine and is solely a preclinical research substance. Not on the WADA Prohibited List. Obtaining it as a research chemical carries considerable quality and safety risks.
Important notice
This site is intended solely for factual, scientifically oriented information about peptides. It does not constitute medical advice, does not replace a consultation with a doctor and contains no recommendations for use in humans.
This site does not sell any substances and names no sources for unapproved substances. For medical questions, please consult qualified medical professionals.
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