Dihexa · DOSSIER

Dihexa

Dihexa · PNB-0408
LEGAL DE · NOT APPROVEDEVIDENCE · PRECLINICAL2 STUDIES
FIG.01 — SIGNAL CHAIN
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Mechanism of action

What Dihexa does in the body — step by step.

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Dihexa is a small angiotensin IV-derived peptide analog modified for improved stability and membrane permeability.

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In preclinical work it is linked to hepatocyte growth factor (HGF) and its receptor c-Met and is said to promote synapse formation (synaptogenesis).

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It has been investigated in the context of learning and memory performance in animal models.

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Research status

How far along is the evidence?

PRECLINICALEARLY CLINICAL STUDIESCLINICALLY ESTABLISHED
Dihexa has so far been studied exclusively preclinically, mainly in rodent models of cognitive performance and neurodegeneration.
Dihexa has so far been studied exclusively preclinically, mainly in rodent models of cognitive performance and neurodegeneration.
Work describes procognitive and synaptogenic effects of angiotensin IV-derived peptides and the development of small analogs for neurodegenerative diseases.
Controlled human studies do not exist.
Safety and efficacy in humans are not demonstrated.
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Known risks

Without human data, safety statements are limited. What is known:

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No human studies — safety profile entirely unknown
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HGF/c-Met activation: theoretical risk of uncontrolled cell growth
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Long-term effects on the nervous system unknown
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Product quality cannot be verified from unapproved sources
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Cited studies

Chronological — links lead to the source.

2014
The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-Met system
PubMed 25187433 →
2015
The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases
PubMed 25455861 →
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Frequently asked questions

What is Dihexa?+

Dihexa is a small angiotensin IV-derived peptide analog modified for improved stability and membrane permeability.

What type of peptide is Dihexa?+

Dihexa belongs to the Neuropeptide class.

What is Dihexa used for?+

In research, Dihexa has primarily been investigated in the context of: Cognition. These are research findings (evidence: preclinical), not proven benefits in humans and not a usage recommendation.

Is Dihexa legal in Germany?+

Dihexa is not approved as a medicine in Germany. Obtaining it outside clinical studies is legally problematic.

Is Dihexa FDA-approved / legal in the US?+

No. Dihexa is not FDA-approved as a drug in the US; it is mostly sold as a research chemical and not for human consumption.

Is Dihexa legal in Canada?+

No. Dihexa is not authorized by Health Canada and not intended for human consumption.

Where can I buy Dihexa?+

Peptica sells nothing and names no sources. Dihexa is "not approved" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.

What is the dosage of Dihexa?+

Peptica publishes no dosing. There are no approved dosing guidelines for Dihexa; figures circulating online stem from animal studies or anecdote, not from validated human protocols. This is not medical advice.

Is Dihexa banned in sport (WADA)?+

Dihexa is currently not on the WADA Prohibited List.

What are the known risks of Dihexa?+

Documented risks include: No human studies — safety profile entirely unknown; HGF/c-Met activation: theoretical risk of uncontrolled cell growth. This is not a complete safety assessment and not medical advice — see the risks section for the full list.

How well researched is Dihexa?+

The evidence is classified as “preclinical”. 2 studies are cited on this page.

What is the molecular weight of Dihexa?+

Dihexa has a molar mass of about 504.7 Da.

Which peptides are related to Dihexa?+

Closely related entries: Semax, Cerebrolysin. A direct side-by-side comparison is available via the compare function.

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Dossier

Legal · Structure · Sources.

LEGAL STATUS BY REGION
Germanynot approved

Dihexa is not approved as a medicine and is solely a research substance. Not on the WADA Prohibited List. Obtaining it as a research chemical carries considerable quality and safety risks.

Legal status varies by country and can change. This is not legal advice.

SOURCES & EXTERNAL DATABASES

Methodology: Peptica compiles publicly available studies and regulatory information and assigns each statement an evidence level. Not medical advice. No warranty.

RELATED PEPTIDES & FURTHER READING
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Community notes

Note: These posts are user opinions and not medical advice. Posts containing dosages, therapeutic claims or purchase recommendations are removed. All entries are manually reviewed before publication.
This page is intended solely for factual, scientifically oriented information. No medical advice · no dosage or usage recommendations · no claims of efficacy · no substitute for medical consultation. Peptica sells no substances. Partner links are marked as advertising; Peptica may earn a commission. © 2026 Peptica · Issue 01