Structure · schematic
Peptide chain · Neuropeptid
Schematic representation of the amino acid chain — not a chemical structural formula. Each node represents one amino acid.
Research areas*
* Contexts in which the peptide has been scientifically studied — not assured or recommended effects.
Mechanism of action
- Dihexa is a small angiotensin IV-derived peptide analog modified for improved stability and membrane permeability.
- In preclinical work it is linked to hepatocyte growth factor (HGF) and its receptor c-Met and is said to promote synapse formation (synaptogenesis).
- It has been investigated in the context of learning and memory performance in animal models.
- The precise molecular mechanism is the subject of research.
Research status
- Dihexa has so far been studied exclusively preclinically, mainly in rodent models of cognitive performance and neurodegeneration.
- Work describes procognitive and synaptogenic effects of angiotensin IV-derived peptides and the development of small analogs for neurodegenerative diseases.
- Controlled human studies do not exist.
- Safety and efficacy in humans are not demonstrated.
Evidence level
Cited studies
Known risks
- 01No human studies — safety profile entirely unknown
- 02HGF/c-Met activation: theoretical risk of uncontrolled cell growth
- 03Long-term effects on the nervous system unknown
- 04Product quality cannot be verified from unapproved sources
Frequently asked questions
What is Dihexa?
Dihexa is a small angiotensin IV-derived peptide analog modified for improved stability and membrane permeability.
What type of peptide is Dihexa?
Dihexa belongs to the Neuropeptide class.
Is Dihexa legal in Germany?
Dihexa is not approved as a medicine in Germany. Obtaining it outside clinical studies is legally problematic.
Where can I buy Dihexa?
Peptica sells nothing and names no sources. Dihexa is "not approved" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.
Is Dihexa banned in sport (WADA)?
Dihexa is currently not on the WADA Prohibited List.
What are the known risks of Dihexa?
Documented risks include: No human studies — safety profile entirely unknown; HGF/c-Met activation: theoretical risk of uncontrolled cell growth. This is not a complete safety assessment and not medical advice — see the risks section for the full list.
How well researched is Dihexa?
The evidence is classified as “preclinical”. 2 studies are cited on this page.
What is the molecular weight of Dihexa?
Dihexa has a molar mass of about 504.7 Da.
Which peptides are related to Dihexa?
Closely related entries: Semax, Cerebrolysin. A direct side-by-side comparison is available via the compare function.
Related entries
Legal status
Germany
not approvedAustria
not approvedSwitzerland
not approvedEU
not approvedUSA
not approvedCanada
not approvedLegal status varies by country and can change. This is not legal advice.
Sources & methodology
- 2 peer-reviewed studies cited, linked to PubMed where available.
- Molecular data verified against PubChem and primary literature. PubChem CID 129010512
- Editorial standard: no dosage guidance, no sources, evidence level stated explicitly.
Last editorially reviewed: 30 May 2026
Legal assessment
Dihexa is not approved as a medicine and is solely a research substance. Not on the WADA Prohibited List. Obtaining it as a research chemical carries considerable quality and safety risks.
Important notice
This site is intended solely for factual, scientifically oriented information about peptides. It does not constitute medical advice, does not replace a consultation with a doctor and contains no recommendations for use in humans.
This site does not sell any substances and names no sources for unapproved substances. For medical questions, please consult qualified medical professionals.
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