Structure · schematic
Peptide chain of 29 amino acids · GHRH-Analog
Sequence
[D-Ala²,Gln⁸,Ala¹⁵,Leu²⁷]-GRF(1–29)-NH₂
Schematic representation of the amino acid chain — not a chemical structural formula. Each node represents one amino acid (shown truncated).
Research areas*
* Contexts in which the peptide has been scientifically studied — not assured or recommended effects.
Mechanism of action
- Mod GRF 1-29 is a synthetic GHRH analog based on the first 29 amino acids of growth hormone-releasing hormone.
- Compared with sermorelin (unmodified GHRH 1-29), it carries four amino acid substitutions (D-Ala², Gln⁸, Ala¹⁵, Leu²⁷) that stabilise it against enzymatic degradation by dipeptidyl peptidase-IV (DPP-IV) and increase receptor affinity.
- Unlike CJC-1295 with DAC, Mod GRF 1-29 has no albumin-binding group — its half-life is therefore only about 30 minutes rather than several days.
- This produces a short, pulsatile GH rise that more closely resembles the physiological release pattern than the sustained baseline elevation of the DAC variant.
Research status
- Mod GRF 1-29 emerged during the preclinical development of long-acting GHRH analogs (ConjuChem) as the backbone prior to DAC conjugation.
- Independent controlled human studies of Mod GRF 1-29 as a final product are practically absent; its pharmacological characterisation derives largely from the context of CJC-1295 development and from general GHRH-analog pharmacology.
- In the research community, Mod GRF 1-29 is discussed as a short-acting alternative to the DAC variant; robust clinical efficacy and safety data for this use are lacking.
Evidence level
Cited studies
Known risks
- 01GH/IGF-1 overstimulation: insulin resistance, acromegaly-like symptoms possible with overdose
- 02Theoretical cancer risk from elevated IGF-1 levels
- 03Fluid retention and joint pain (known GH class effects)
- 04No independent clinical long-term data
- 05Legal risk: possession may be punishable under ADBG/DmMV
- 06Product quality cannot be verified from unapproved sources
Frequently asked questions
What is Mod GRF 1-29?
Mod GRF 1-29 is a synthetic GHRH analog based on the first 29 amino acids of growth hormone-releasing hormone.
What type of peptide is Mod GRF 1-29?
Mod GRF 1-29 belongs to the GHRH analog class.
Is Mod GRF 1-29 legal in Germany?
Mod GRF 1-29 is not approved as a medicine in Germany. Obtaining it outside clinical studies is legally problematic. It is additionally relevant under the German Doping Agent Quantity Ordinance (DmMV).
Where can I buy Mod GRF 1-29?
Peptica sells nothing and names no sources. Mod GRF 1-29 is "not approved" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.
Is Mod GRF 1-29 banned in sport (WADA)?
Yes. Mod GRF 1-29 is on the WADA Prohibited List and is therefore banned in competitive sport.
What are the known risks of Mod GRF 1-29?
Documented risks include: GH/IGF-1 overstimulation: insulin resistance, acromegaly-like symptoms possible with overdose; Theoretical cancer risk from elevated IGF-1 levels. This is not a complete safety assessment and not medical advice — see the risks section for the full list.
How well researched is Mod GRF 1-29?
The evidence is classified as “preclinical”. 2 studies are cited on this page.
What is the molecular weight of Mod GRF 1-29?
Mod GRF 1-29 has a molar mass of about 3367.9 Da, with a plasma half-life of ~30 minutes.
Which peptides are related to Mod GRF 1-29?
Closely related entries: CJC-1295, Ipamorelin, Sermorelin. A direct side-by-side comparison is available via the compare function.
Related entries
Legal status
Germany
not approvedAustria
not approvedSwitzerland
not approvedEU
not approvedUSA
not approvedCanada
not approvedLegal status varies by country and can change. This is not legal advice.
Sources & methodology
- 2 peer-reviewed studies cited, linked to PubMed where available.
- Molecular data verified against PubChem and primary literature.
- Editorial standard: no dosage guidance, no sources, evidence level stated explicitly.
Last editorially reviewed: 28 May 2026
Legal assessment
As a GHRH analog, Mod GRF 1-29 is listed on the WADA Prohibited List (S2). It falls under the German Anti-Doping Act (ADBG) and is covered by the German Doping Agent Quantity Ordinance (DmMV) — possession of more than a minor quantity may be punishable under § 4 ADBG. Not approved as a medicine in the EU. Classified as not to be obtained.
Important notice
This site is intended solely for factual, scientifically oriented information about peptides. It does not constitute medical advice, does not replace a consultation with a doctor and contains no recommendations for use in humans.
This site does not sell any substances and names no sources for unapproved substances. For medical questions, please consult qualified medical professionals.
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