DSIP · DOSSIER

DSIP

Delta Sleep-Inducing Peptide · Delta-Schlaf-induzierendes Peptid · Peptide · 9 AS
LEGAL DE · UNCLASSIFIEDEVIDENCE · PRECLINICAL3 STUDIES
FIG.01 — SIGNAL CHAIN
WAGGDASGE · ~848.8 Da
02

Mechanism of action

What DSIP does in the body — step by step.

01

DSIP is a nonapeptide (sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) isolated in 1977 from the thalamic venous blood of rabbits.

02

Its molecular mechanisms of action remain incompletely understood.

03

Interactions with GABA receptors, a modulating effect on the hypothalamic-pituitary axis and neuroprotective properties via antioxidant pathways have been discussed.

03

Research status

How far along is the evidence?

PRECLINICALEARLY CLINICAL STUDIESCLINICALLY ESTABLISHED
Research on DSIP was active in the 1980s and early 1990s and has largely stagnated since.
Research on DSIP was active in the 1980s and early 1990s and has largely stagnated since.
Early human studies investigated intravenous DSIP administration in insomnia and withdrawal syndromes (alcohol, opioids) and observed, in small cohorts, signs of improved sleep quality and reduced withdrawal symptoms.
Methodological shortcomings (small sample sizes, lack of placebo control, no replication) preclude valid conclusions.
No current clinical development programmes exist; interest in academic research is low.
04

Known risks

Without human data, safety statements are limited. What is known:

01
Lack of current safety data — long-term profile in humans unknown
02
Possible interactions with central nervous system pathways not sufficiently studied
03
Quality control not guaranteed from research-chemical sources
04
No established dosing protocols for safe human use
05

Cited studies

Chronological — links lead to the source.

1984
Delta sleep-inducing peptide (DSIP): a review
PubMed 6096390 →
1985
DSIP-like material in human blood and cerebrospinal fluid
PubMed 2987517 →
1986
Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients
PubMed 3806347 →
06

Frequently asked questions

What is DSIP?+

DSIP is a nonapeptide (sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) isolated in 1977 from the thalamic venous blood of rabbits.

What type of peptide is DSIP?+

DSIP belongs to the Neuropeptide class.

What is DSIP used for?+

In research, DSIP has primarily been investigated in the context of: Cognition. These are research findings (evidence: preclinical), not proven benefits in humans and not a usage recommendation.

Is DSIP legal in Germany?+

The regulatory status of DSIP in Germany is not clearly classified.

Is DSIP FDA-approved / legal in the US?+

No. DSIP is not FDA-approved as a drug in the US; it is mostly sold as a research chemical and not for human consumption.

Is DSIP legal in Canada?+

No. DSIP is not authorized by Health Canada and not intended for human consumption.

Where can I buy DSIP?+

Peptica sells nothing and names no sources. DSIP is "unclassified" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.

What is the dosage of DSIP?+

Peptica publishes no dosing. There are no approved dosing guidelines for DSIP; figures circulating online stem from animal studies or anecdote, not from validated human protocols. This is not medical advice.

Is DSIP banned in sport (WADA)?+

DSIP is currently not on the WADA Prohibited List.

What are the known risks of DSIP?+

Documented risks include: Lack of current safety data — long-term profile in humans unknown; Possible interactions with central nervous system pathways not sufficiently studied. This is not a complete safety assessment and not medical advice — see the risks section for the full list.

How well researched is DSIP?+

The evidence is classified as “preclinical”. 3 studies are cited on this page.

What is the molecular weight of DSIP?+

DSIP has a molar mass of about 848.8 Da.

Which peptides are related to DSIP?+

Closely related entries: Semax, Selank. A direct side-by-side comparison is available via the compare function.

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Dossier

Legal · Structure · Sources.

LEGAL STATUS BY REGION
Germanyunclassified

DSIP is not an approved medicine in the EU and is not on the WADA Prohibited List. Importing it as a research chemical is a legal grey area — depending on the specific intended use, the German Medicines Act (AMG) may apply. In the absence of clinical data, a sound risk-benefit assessment is not possible.

Legal status varies by country and can change. This is not legal advice.

STRUCTURE & MOLECULE
H₂NWAGGDASGECOOH
9
AMINO ACIDS
~848.8
MOL. WEIGHT (Da)
Very short
HALF-LIFE
SOURCES & EXTERNAL DATABASES

Methodology: Peptica compiles publicly available studies and regulatory information and assigns each statement an evidence level. Not medical advice. No warranty.

RELATED PEPTIDES & FURTHER READING
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Community notes

Note: These posts are user opinions and not medical advice. Posts containing dosages, therapeutic claims or purchase recommendations are removed. All entries are manually reviewed before publication.
This page is intended solely for factual, scientifically oriented information. No medical advice · no dosage or usage recommendations · no claims of efficacy · no substitute for medical consultation. Peptica sells no substances. Partner links are marked as advertising; Peptica may earn a commission. © 2026 Peptica · Issue 01