ACE-031
Mechanism of action
What ACE-031 does in the body — step by step.
ACE-031 is a soluble decoy receptor: a fusion protein of the extracellular domain of activin receptor type IIB (ActRIIB) and an antibody Fc portion.
It binds myostatin and related ligands before they can dock onto their cellular receptor, thereby removing their growth-inhibiting effect on muscle.
An increase in muscle mass has consequently been described in studies.
Research status
How far along is the evidence?
Known risks
Without human data, safety statements are limited. What is known:
Cited studies
Chronological — links lead to the source.
Frequently asked questions
What is ACE-031?+
ACE-031 is a soluble decoy receptor: a fusion protein of the extracellular domain of activin receptor type IIB (ActRIIB) and an antibody Fc portion.
What type of peptide is ACE-031?+
ACE-031 belongs to the Other class.
What is ACE-031 used for?+
In research, ACE-031 has primarily been investigated in the context of: Muscle growth. These are research findings (evidence: early clinical studies), not proven benefits in humans and not a usage recommendation.
Is ACE-031 legal in Germany?+
ACE-031 is not approved as a medicine in Germany. Obtaining it outside clinical studies is legally problematic.
Is ACE-031 FDA-approved / legal in the US?+
No. ACE-031 is not FDA-approved as a drug in the US; it is mostly sold as a research chemical and not for human consumption.
Is ACE-031 legal in Canada?+
No. ACE-031 is not authorized by Health Canada and not intended for human consumption.
Where can I buy ACE-031?+
Peptica sells nothing and names no sources. ACE-031 is "not approved" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.
What is the dosage of ACE-031?+
Peptica publishes no dosing. There are no approved dosing guidelines for ACE-031; figures circulating online stem from animal studies or anecdote, not from validated human protocols. This is not medical advice.
Is ACE-031 banned in sport (WADA)?+
Yes. ACE-031 is on the WADA Prohibited List and is therefore banned in competitive sport.
What are the known risks of ACE-031?+
Documented risks include: Trial stopped due to bleeding tendency and telangiectasia; Nosebleeds and gum bleeding described. This is not a complete safety assessment and not medical advice — see the risks section for the full list.
How well researched is ACE-031?+
The evidence is classified as “early clinical studies”. 2 studies are cited on this page.
Which peptides are related to ACE-031?+
Closely related entries: IGF-1 LR3, MGF, IGF-1 DES. A direct side-by-side comparison is available via the compare function.
Dossier
Legal · Structure · Sources.
ACE-031 is not approved as a medicine; clinical development was discontinued. As a myostatin-inhibiting agent it falls under the WADA Prohibited List (S4, myostatin inhibitors). Obtaining it as a research chemical is illegal and carries considerable safety risks.
Legal status varies by country and can change. This is not legal advice.
Methodology: Peptica compiles publicly available studies and regulatory information and assigns each statement an evidence level. Not medical advice. No warranty.