IGF-1 DES
Mechanism of action
What IGF-1 DES does in the body — step by step.
IGF-1 DES is a truncated variant of insulin-like growth factor 1 lacking the first three N-terminal amino acids (DES(1-3)IGF-1).
This truncation makes the molecule bind much more weakly to IGF binding proteins, allowing higher relative activity at the IGF-1 receptor in tissue.
In cell models an increased potency relative to full-length IGF-1 has been described.
Research status
How far along is the evidence?
Known risks
Without human data, safety statements are limited. What is known:
Cited studies
Chronological — links lead to the source.
Frequently asked questions
What is IGF-1 DES?+
IGF-1 DES is a truncated variant of insulin-like growth factor 1 lacking the first three N-terminal amino acids (DES(1-3)IGF-1).
What type of peptide is IGF-1 DES?+
IGF-1 DES belongs to the IGF / insulin analog class.
What is IGF-1 DES used for?+
In research, IGF-1 DES has primarily been investigated in the context of: Muscle growth, Recovery. These are research findings (evidence: preclinical), not proven benefits in humans and not a usage recommendation.
Is IGF-1 DES legal in Germany?+
IGF-1 DES is not approved as a medicine in Germany. Obtaining it outside clinical studies is legally problematic. It is additionally relevant under the German Doping Agent Quantity Ordinance (DmMV).
Is IGF-1 DES FDA-approved / legal in the US?+
No. IGF-1 DES is not FDA-approved as a drug in the US; it is mostly sold as a research chemical and not for human consumption.
Is IGF-1 DES legal in Canada?+
No. IGF-1 DES is not authorized by Health Canada and not intended for human consumption.
Where can I buy IGF-1 DES?+
Peptica sells nothing and names no sources. IGF-1 DES is "not approved" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.
What is the dosage of IGF-1 DES?+
Peptica publishes no dosing. There are no approved dosing guidelines for IGF-1 DES; figures circulating online stem from animal studies or anecdote, not from validated human protocols. This is not medical advice.
Is IGF-1 DES banned in sport (WADA)?+
Yes. IGF-1 DES is on the WADA Prohibited List and is therefore banned in competitive sport.
What are the known risks of IGF-1 DES?+
Documented risks include: No controlled human studies — safety profile not established; Hypoglycaemia risk via IGF/insulin signalling. This is not a complete safety assessment and not medical advice — see the risks section for the full list.
How well researched is IGF-1 DES?+
The evidence is classified as “preclinical”. 2 studies are cited on this page.
What is the molecular weight of IGF-1 DES?+
IGF-1 DES has a molar mass of about 7371.8 Da, with a plasma half-life of very short (minutes).
Which peptides are related to IGF-1 DES?+
Closely related entries: IGF-1, IGF-1 LR3. A direct side-by-side comparison is available via the compare function.
Dossier
Legal · Structure · Sources.
IGF-1 DES is not approved as a medicine. As an IGF-1 variant it falls under the WADA Prohibited List (S2) and is doping-relevant (ADBG/DmMV). Obtaining it as a research chemical is illegal and carries considerable safety risks.
Legal status varies by country and can change. This is not legal advice.
Methodology: Peptica compiles publicly available studies and regulatory information and assigns each statement an evidence level. Not medical advice. No warranty.