MGF
Mechanism of action
What MGF does in the body — step by step.
MGF (mechano growth factor) is a splice variant of the IGF-1 gene (IGF-1 Ec) expressed mainly after mechanical muscle loading.
Its characteristic C-terminal E-peptide is discussed as a separate signal thought to promote the activation and proliferation of muscle satellite cells.
The pegylated form (PEG-MGF) is intended to extend the very short half-life of the native peptide.
Research status
How far along is the evidence?
Known risks
Without human data, safety statements are limited. What is known:
Cited studies
Chronological — links lead to the source.
Frequently asked questions
What is MGF?+
MGF (mechano growth factor) is a splice variant of the IGF-1 gene (IGF-1 Ec) expressed mainly after mechanical muscle loading.
What type of peptide is MGF?+
MGF belongs to the IGF / insulin analog class.
What is MGF used for?+
In research, MGF has primarily been investigated in the context of: Muscle growth, Recovery. These are research findings (evidence: preclinical), not proven benefits in humans and not a usage recommendation.
Is MGF legal in Germany?+
MGF is not approved as a medicine in Germany. Obtaining it outside clinical studies is legally problematic. It is additionally relevant under the German Doping Agent Quantity Ordinance (DmMV).
Is MGF FDA-approved / legal in the US?+
No. MGF is not FDA-approved as a drug in the US; it is mostly sold as a research chemical and not for human consumption.
Is MGF legal in Canada?+
No. MGF is not authorized by Health Canada and not intended for human consumption.
Where can I buy MGF?+
Peptica sells nothing and names no sources. MGF is "not approved" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.
What is the dosage of MGF?+
Peptica publishes no dosing. There are no approved dosing guidelines for MGF; figures circulating online stem from animal studies or anecdote, not from validated human protocols. This is not medical advice.
Is MGF banned in sport (WADA)?+
Yes. MGF is on the WADA Prohibited List and is therefore banned in competitive sport.
What are the known risks of MGF?+
Documented risks include: No controlled human studies — safety profile not established; Growth-factor activity: theoretical risk of promoting tumours. This is not a complete safety assessment and not medical advice — see the risks section for the full list.
How well researched is MGF?+
The evidence is classified as “preclinical”. 2 studies are cited on this page.
Which peptides are related to MGF?+
Closely related entries: IGF-1, IGF-1 LR3. A direct side-by-side comparison is available via the compare function.
Dossier
Legal · Structure · Sources.
MGF/PEG-MGF is not approved as a medicine. As a growth factor of the IGF-1 family it falls under the WADA Prohibited List (S2) and is doping-relevant (ADBG/DmMV). Obtaining it as a research chemical is illegal and carries considerable safety risks.
Legal status varies by country and can change. This is not legal advice.
Methodology: Peptica compiles publicly available studies and regulatory information and assigns each statement an evidence level. Not medical advice. No warranty.