Substance class
Reproduktionspeptid
2 entries
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Kisspeptin
Kisspeptin-10
Kisspeptin is a neuropeptide derived from the KISS1 gene, occurring in several biologically active forms (KP-10, KP-13, KP-14, KP-54). It binds the G-protein-coupled receptor KISS1R (formerly GPR54) on hypothalamic GnRH neurons and is regarded as a central regulator of pulsatile GnRH release — the master pacemaker of the hypothalamic-pituitary-gonadal axis. Kisspeptin mediates the activation of puberty, governs the cyclic release of LH/FSH and mediates the negative and positive feedback mechanisms of sex hormones at the hypothalamic level. Exogenous kisspeptin administration reliably stimulates LH and FSH pulses and, downstream, testosterone and oestrogen.
Gonadorelin (GnRH)
Gonadorelin
Gonadorelin is the synthetic form of the body's own gonadotropin-releasing hormone (GnRH), a decapeptide from the hypothalamus. It binds to GnRH receptors in the pituitary gland and there governs the release of the gonadotropins LH and FSH. The pattern is decisive: pulsatile administration stimulates the gonadotropic axis, whereas continuous, sustained stimulation paradoxically down-regulates it (desensitisation).