Kisspeptin
Mechanism of action
What Kisspeptin does in the body — step by step.
Kisspeptin is a neuropeptide derived from the KISS1 gene, occurring in several biologically active forms (KP-10, KP-13, KP-14, KP-54).
It binds the G-protein-coupled receptor KISS1R (formerly GPR54) on hypothalamic GnRH neurons and is regarded as a central regulator of pulsatile GnRH release — the master pacemaker of the hypothalamic-pituitary-gonadal axis.
Kisspeptin mediates the activation of puberty, governs the cyclic release of LH/FSH and mediates the negative and positive feedback mechanisms of sex hormones at the hypothalamic level.
Research status
How far along is the evidence?
Known risks
Without human data, safety statements are limited. What is known:
Cited studies
Chronological — links lead to the source.
Frequently asked questions
What is Kisspeptin?+
Kisspeptin is a neuropeptide derived from the KISS1 gene, occurring in several biologically active forms (KP-10, KP-13, KP-14, KP-54).
What type of peptide is Kisspeptin?+
Kisspeptin belongs to the Reproductive peptide class.
What is Kisspeptin used for?+
In research, Kisspeptin has primarily been investigated in the context of: Libido. These are research findings (evidence: early clinical studies), not proven benefits in humans and not a usage recommendation.
Is Kisspeptin legal in Germany?+
Kisspeptin is not approved as a medicine in Germany. Obtaining it outside clinical studies is legally problematic.
Is Kisspeptin FDA-approved / legal in the US?+
No. Kisspeptin is not FDA-approved as a drug in the US; it is mostly sold as a research chemical and not for human consumption.
Is Kisspeptin legal in Canada?+
No. Kisspeptin is not authorized by Health Canada and not intended for human consumption.
Where can I buy Kisspeptin?+
Peptica sells nothing and names no sources. Kisspeptin is "not approved" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.
What is the dosage of Kisspeptin?+
Peptica publishes no dosing. There are no approved dosing guidelines for Kisspeptin; figures circulating online stem from animal studies or anecdote, not from validated human protocols. This is not medical advice.
Is Kisspeptin banned in sport (WADA)?+
Kisspeptin is currently not on the WADA Prohibited List.
What are the known risks of Kisspeptin?+
Documented risks include: Flushing and mild nausea described after injection; Potential desensitisation with continuous administration (KISS1R downregulation). This is not a complete safety assessment and not medical advice — see the risks section for the full list.
How well researched is Kisspeptin?+
The evidence is classified as “early clinical studies”. 3 studies are cited on this page.
What is the molecular weight of Kisspeptin?+
Kisspeptin has a molar mass of about 1302.4 Da.
Which peptides are related to Kisspeptin?+
Closely related entries: PT-141. A direct side-by-side comparison is available via the compare function.
Dossier
Legal · Structure · Sources.
Kisspeptin is not an approved medicine in the EU. Clinical use occurs exclusively within regulated studies. Not on the WADA Prohibited List. Importing it as a research chemical may, depending on the context, fall under the German Medicines Act (AMG).
Legal status varies by country and can change. This is not legal advice.
Methodology: Peptica compiles publicly available studies and regulatory information and assigns each statement an evidence level. Not medical advice. No warranty.