Structure · schematic
Peptide chain of 10 amino acids · Reproduktionspeptid
Sequence
YNWNSFGLRF-NH₂ (Kisspeptin-10)
Schematic representation of the amino acid chain — not a chemical structural formula. Each node represents one amino acid.
Research areas*
* Contexts in which the peptide has been scientifically studied — not assured or recommended effects.
Mechanism of action
- Kisspeptin is a neuropeptide derived from the KISS1 gene, occurring in several biologically active forms (KP-10, KP-13, KP-14, KP-54).
- It binds the G-protein-coupled receptor KISS1R (formerly GPR54) on hypothalamic GnRH neurons and is regarded as a central regulator of pulsatile GnRH release — the master pacemaker of the hypothalamic-pituitary-gonadal axis.
- Kisspeptin mediates the activation of puberty, governs the cyclic release of LH/FSH and mediates the negative and positive feedback mechanisms of sex hormones at the hypothalamic level.
- Exogenous kisspeptin administration reliably stimulates LH and FSH pulses and, downstream, testosterone and oestrogen.
Research status
- Kisspeptin is one of the most intensively researched reproductive-medicine peptides of the past decade.
- Clinical Phase II studies (particularly at Imperial College London, Abbara et al.) investigated kisspeptin-54 and -10 in hypothalamic amenorrhoea, hypogonadotropic hypogonadism and as an alternative to hCG in IVF treatment.
- In these studies, kisspeptin reliably triggered the LH peak for egg maturation with a reduced risk of ovarian hyperstimulation syndrome (OHSS).
- In the context of testosterone replacement therapy, kisspeptin is discussed as a means of maintaining the suppressed endogenous GnRH axis — robust RCT data for this off-label use are lacking.
Evidence level
Cited studies
Known risks
- 01Flushing and mild nausea described after injection
- 02Potential desensitisation with continuous administration (KISS1R downregulation)
- 03Effect is strictly dose-dependent — subtherapeutic doses have no LH effect, supratherapeutic doses cause desensitisation
- 04Use in existing hormone-dependent conditions (PCOS, hormone-dependent tumours) not studied
- 05No long-term safety data outside reproductive-medicine study settings
Frequently asked questions
What is Kisspeptin?
Kisspeptin is a neuropeptide derived from the KISS1 gene, occurring in several biologically active forms (KP-10, KP-13, KP-14, KP-54).
What type of peptide is Kisspeptin?
Kisspeptin belongs to the Reproductive peptide class.
Is Kisspeptin legal in Germany?
Kisspeptin is not approved as a medicine in Germany. Obtaining it outside clinical studies is legally problematic.
Where can I buy Kisspeptin?
Peptica sells nothing and names no sources. Kisspeptin is "not approved" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.
Is Kisspeptin banned in sport (WADA)?
Kisspeptin is currently not on the WADA Prohibited List.
What are the known risks of Kisspeptin?
Documented risks include: Flushing and mild nausea described after injection; Potential desensitisation with continuous administration (KISS1R downregulation). This is not a complete safety assessment and not medical advice — see the risks section for the full list.
How well researched is Kisspeptin?
The evidence is classified as “early clinical studies”. 3 studies are cited on this page.
What is the molecular weight of Kisspeptin?
Kisspeptin has a molar mass of about 1302.4 Da.
Which peptides are related to Kisspeptin?
Closely related entries: PT-141. A direct side-by-side comparison is available via the compare function.
Related entries
Legal status
Germany
not approvedAustria
not approvedSwitzerland
not approvedEU
not approvedUSA
not approvedCanada
not approvedLegal status varies by country and can change. This is not legal advice.
Sources & methodology
- 3 peer-reviewed studies cited, linked to PubMed where available.
- Molecular data verified against PubChem and primary literature. PubChem CID 25240297
- Editorial standard: no dosage guidance, no sources, evidence level stated explicitly.
Last editorially reviewed: 28 May 2026
Legal assessment
Kisspeptin is not an approved medicine in the EU. Clinical use occurs exclusively within regulated studies. Not on the WADA Prohibited List. Importing it as a research chemical may, depending on the context, fall under the German Medicines Act (AMG).
Important notice
This site is intended solely for factual, scientifically oriented information about peptides. It does not constitute medical advice, does not replace a consultation with a doctor and contains no recommendations for use in humans.
This site does not sell any substances and names no sources for unapproved substances. For medical questions, please consult qualified medical professionals.
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