PT-141
Acts directly in the brain; in large trials it increased desire in women with low libido.
What it does in the body
Findings, each with its evidence level — animal data kept visibly apart from what's unproven in humans.
Acts directly in the brain; in large trials it increased desire in women with low libido.
PROVEN IN HUMANSUnlike Viagra and similar, it works via the brain, not by widening blood vessels.
MECHANISM ONLYApproved in the US since 2019 (as Vyleesi) for women with low sexual desire — not in the EU.
PROVEN IN HUMANSFor men (erectile issues) only early studies exist — no approval was ever sought.
UNPROVEN IN HUMANSMechanism of action
What PT-141 does in the body — step by step.
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide and an agonist at melanocortin receptors, particularly MC3R and MC4R.
It is a metabolite of Melanotan II but contains no acetyl group at the N-terminus.
Unlike peripheral vasodilators (e.g. PDE-5 inhibitors), PT-141 acts primarily centrally via the hypothalamus and other CNS areas involved in regulating sexual desire.
Research status
How far along is the evidence?
Known risks
Without human data, safety statements are limited. What is known:
Cited studies
Chronological — links lead to the source.
Frequently asked questions
What is PT-141?+
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide and an agonist at melanocortin receptors, particularly MC3R and MC4R.
What type of peptide is PT-141?+
PT-141 belongs to the Melanocortin class.
What is PT-141 used for?+
In research, PT-141 has primarily been investigated in the context of: Libido. These are research findings (evidence: clinically established), not proven benefits in humans and not a usage recommendation.
Is PT-141 legal in Germany?+
PT-141 is not approved as a medicine in Germany. Obtaining it outside clinical studies is legally problematic.
Is PT-141 FDA-approved / legal in the US?+
PT-141 is a prescription, FDA-approved medication in the US.
Is PT-141 legal in Canada?+
No. PT-141 is not authorized by Health Canada and not intended for human consumption.
Where can I buy PT-141?+
Peptica sells nothing and names no sources. PT-141 is "not approved" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.
What is the dosage of PT-141?+
Peptica publishes no dosing. There are no approved dosing guidelines for PT-141; figures circulating online stem from animal studies or anecdote, not from validated human protocols. This is not medical advice.
Is PT-141 banned in sport (WADA)?+
PT-141 is currently not on the WADA Prohibited List.
What are the known risks of PT-141?+
Documented risks include: Nausea: the most common side effect in clinical studies (about 40% of users), dose-limiting in about 13%; Blood pressure increase: transient hypertension described after administration; contraindicated in cardiovascular disease. This is not a complete safety assessment and not medical advice — see the risks section for the full list.
How well researched is PT-141?+
The evidence is classified as “clinically established”. 2 studies are cited on this page.
What is the molecular weight of PT-141?+
PT-141 has a molar mass of about 1025.2 Da, with a plasma half-life of ~2.7 hours.
Which peptides are related to PT-141?+
Closely related entries: Melanotan II. A direct side-by-side comparison is available via the compare function.
Dossier
Legal · Structure · Sources.
PT-141 / bremelanotide is FDA-approved in the USA as Vyleesi (HSDD in premenopausal women) but has no EMA approval for Europe. In Germany, the substance is not approved as a medicine; obtaining it without a prescription is not legal. Not listed on the WADA Prohibited List.
Legal status varies by country and can change. This is not legal advice.
Methodology: Peptica compiles publicly available studies and regulatory information and assigns each statement an evidence level. Not medical advice. No warranty.