Gonadorelin (GnRH)
Mechanism of action
What Gonadorelin (GnRH) does in the body — step by step.
Gonadorelin is the synthetic form of the body's own gonadotropin-releasing hormone (GnRH), a decapeptide from the hypothalamus.
It binds to GnRH receptors in the pituitary gland and there governs the release of the gonadotropins LH and FSH.
The pattern is decisive: pulsatile administration stimulates the gonadotropic axis, whereas continuous, sustained stimulation paradoxically down-regulates it (desensitisation).
Research status
How far along is the evidence?
Known risks
Without human data, safety statements are limited. What is known:
Cited studies
Chronological — links lead to the source.
Frequently asked questions
What is Gonadorelin (GnRH)?+
Gonadorelin is the synthetic form of the body's own gonadotropin-releasing hormone (GnRH), a decapeptide from the hypothalamus.
What type of peptide is Gonadorelin (GnRH)?+
Gonadorelin (GnRH) belongs to the Reproductive peptide class.
What is Gonadorelin (GnRH) used for?+
In research, Gonadorelin (GnRH) has primarily been investigated in the context of: Libido. These are research findings (evidence: clinically established), not proven benefits in humans and not a usage recommendation.
Is Gonadorelin (GnRH) legal in Germany?+
Gonadorelin (GnRH) is prescription-only in Germany and may only be obtained with a medical prescription.
Is Gonadorelin (GnRH) FDA-approved / legal in the US?+
The FDA status of Gonadorelin (GnRH) is not clearly classified.
Is Gonadorelin (GnRH) legal in Canada?+
The regulatory status of Gonadorelin (GnRH) in Canada is not clearly classified.
Where can I buy Gonadorelin (GnRH)?+
Peptica sells nothing and names no sources. Gonadorelin (GnRH) is "prescription-only" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.
What is the dosage of Gonadorelin (GnRH)?+
Peptica publishes no dosing. Gonadorelin (GnRH) is a prescription medicine — any dosing is determined individually by a physician. This is not medical advice.
Is Gonadorelin (GnRH) banned in sport (WADA)?+
Gonadorelin (GnRH) is currently not on the WADA Prohibited List.
What are the known risks of Gonadorelin (GnRH)?+
Documented risks include: Effect strongly dependent on administration pattern (pulsatile vs. continuous); Headache, nausea, flushing possible. This is not a complete safety assessment and not medical advice — see the risks section for the full list.
How well researched is Gonadorelin (GnRH)?+
The evidence is classified as “clinically established”. 2 studies are cited on this page.
What is the molecular weight of Gonadorelin (GnRH)?+
Gonadorelin (GnRH) has a molar mass of about 1182.3 Da, with a plasma half-life of ~2–4 minutes.
Which peptides are related to Gonadorelin (GnRH)?+
Closely related entries: Kisspeptin, HCG. A direct side-by-side comparison is available via the compare function.
Dossier
Legal · Structure · Sources.
Gonadorelin is approved as a diagnostic and therapeutic medicine and is prescription-only. Obtaining it without a medical prescription is illegal in Germany under § 48 AMG. GnRH itself is not on the WADA Prohibited List, although related substances are regulated in the doping context.
Legal status varies by country and can change. This is not legal advice.
Methodology: Peptica compiles publicly available studies and regulatory information and assigns each statement an evidence level. Not medical advice. No warranty.