Structure · schematic
Peptide chain of 10 amino acids · Reproduktionspeptid
Sequence
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂
Schematic representation of the amino acid chain — not a chemical structural formula. Each node represents one amino acid.
Research areas*
* Contexts in which the peptide has been scientifically studied — not assured or recommended effects.
Mechanism of action
- Gonadorelin is the synthetic form of the body's own gonadotropin-releasing hormone (GnRH), a decapeptide from the hypothalamus.
- It binds to GnRH receptors in the pituitary gland and there governs the release of the gonadotropins LH and FSH.
- The pattern is decisive: pulsatile administration stimulates the gonadotropic axis, whereas continuous, sustained stimulation paradoxically down-regulates it (desensitisation).
Research status
- Gonadorelin has long been clinically established, both diagnostically (the GnRH test) and therapeutically.
- Reviews describe pulsatile GnRH administration as a means of inducing puberty and fertility in congenital hypogonadotropic hypogonadism.
- Further reviews address physiological and disordered "mini-puberty" and therapeutic replacement concepts.
- The effect depends strongly on the administration pattern.
Evidence level
Cited studies
Known risks
- 01Effect strongly dependent on administration pattern (pulsatile vs. continuous)
- 02Headache, nausea, flushing possible
- 03Local injection-site reactions
- 04Hormonal dysregulation with improper use
- 05Rare hypersensitivity reactions
Frequently asked questions
What is Gonadorelin (GnRH)?
Gonadorelin is the synthetic form of the body's own gonadotropin-releasing hormone (GnRH), a decapeptide from the hypothalamus.
What type of peptide is Gonadorelin (GnRH)?
Gonadorelin (GnRH) belongs to the Reproductive peptide class.
Is Gonadorelin (GnRH) legal in Germany?
Gonadorelin (GnRH) is prescription-only in Germany and may only be obtained with a medical prescription.
Where can I buy Gonadorelin (GnRH)?
Peptica sells nothing and names no sources. Gonadorelin (GnRH) is "prescription-only" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.
Is Gonadorelin (GnRH) banned in sport (WADA)?
Gonadorelin (GnRH) is currently not on the WADA Prohibited List.
What are the known risks of Gonadorelin (GnRH)?
Documented risks include: Effect strongly dependent on administration pattern (pulsatile vs. continuous); Headache, nausea, flushing possible. This is not a complete safety assessment and not medical advice — see the risks section for the full list.
How well researched is Gonadorelin (GnRH)?
The evidence is classified as “clinically established”. 2 studies are cited on this page.
What is the molecular weight of Gonadorelin (GnRH)?
Gonadorelin (GnRH) has a molar mass of about 1182.3 Da, with a plasma half-life of ~2–4 minutes.
Which peptides are related to Gonadorelin (GnRH)?
Closely related entries: Kisspeptin, HCG. A direct side-by-side comparison is available via the compare function.
Related entries
Legal status
Germany
prescription-onlyAustria
prescription-onlySwitzerland
prescription-onlyEU
approved medicineUSA
unclassifiedCanada
unclassifiedLegal status varies by country and can change. This is not legal advice.
Sources & methodology
- 2 peer-reviewed studies cited, linked to PubMed where available.
- Molecular data verified against PubChem and primary literature. PubChem CID 638793
- Editorial standard: no dosage guidance, no sources, evidence level stated explicitly.
Last editorially reviewed: 30 May 2026
Important notice
This site is intended solely for factual, scientifically oriented information about peptides. It does not constitute medical advice, does not replace a consultation with a doctor and contains no recommendations for use in humans.
This site does not sell any substances and names no sources for unapproved substances. For medical questions, please consult qualified medical professionals.
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