Substance class
GHRH-Analog
4 entries
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CJC-1295
CJC 1295
CJC-1295 is a synthetic analog of the body's own growth hormone-releasing hormone (GHRH). The substance binds selectively to the GHRH receptor in the pituitary, where it stimulates the pulsatile release of growth hormone (GH). Characteristic of CJC-1295 is the DAC modification (Drug Affinity Complex): a maleimidopropionic acid group binds covalently to circulating serum albumin, thereby extending the half-life from a few minutes to several days. This produces a sustained elevation of the GH/IGF-1 baseline rather than physiological pulses. The variant without the DAC modification is listed separately as Mod GRF 1-29 and has a markedly shorter duration of action.
Tesamorelin
Tesamoreline
Tesamorelin is a synthetic analog of human GHRH (growth hormone-releasing hormone), consisting of the complete GHRH(1-44) peptide with a trans-3-hexenoic acid modification at the N-terminus. This modification increases stability against enzymatic degradation by dipeptidyl peptidase IV (DPP-IV). Tesamorelin stimulates pituitary GH secretion in a physiological, pulsatile manner, as it preserves the endogenous feedback regulation via IGF-1 and somatostatin. Unlike exogenous GH, the physiological regulatory mechanism remains intact.
Sermorelin
GHRH(1-29)-NH₂
Sermorelin is a synthetic 29-amino-acid peptide corresponding to the first 29 amino acids of endogenous growth hormone-releasing hormone (GHRH) — the shortest sequence that still retains full biological activity at the GHRH receptor (GHRHR). By binding to GHRHR in the somatotroph cells of the anterior pituitary, sermorelin stimulates the synthesis and pulsatile release of growth hormone (GH). Compared with CJC-1295, sermorelin has a shorter biological half-life (approx. 10–20 minutes), producing more physiological, short-lived GH pulses than long-acting GHRH analogs.
Mod GRF 1-29
Modified GRF (1-29)
Mod GRF 1-29 is a synthetic GHRH analog based on the first 29 amino acids of growth hormone-releasing hormone. Compared with sermorelin (unmodified GHRH 1-29), it carries four amino acid substitutions (D-Ala², Gln⁸, Ala¹⁵, Leu²⁷) that stabilise it against enzymatic degradation by dipeptidyl peptidase-IV (DPP-IV) and increase receptor affinity. Unlike CJC-1295 with DAC, Mod GRF 1-29 has no albumin-binding group — its half-life is therefore only about 30 minutes rather than several days. This produces a short, pulsatile GH rise that more closely resembles the physiological release pattern than the sustained baseline elevation of the DAC variant.