Direct comparison
Tesamorelin vs Sermorelin
Class
GHRH analog
GHRH analog
Mechanism
Tesamorelin is a synthetic analog of human GHRH (growth hormone-releasing hormone), consisting of the complete GHRH(1-44) peptide with a trans-3-hexenoic acid modification at the N-terminus.
Sermorelin is a synthetic 29-amino-acid peptide corresponding to the first 29 amino acids of endogenous growth hormone-releasing hormone (GHRH) — the shortest sequence that still retains full biological activity at the GHRH receptor (GHRHR).
Studied effects
Muscle growth, Metabolism
Muscle growth, Anti-aging
Evidence level
clinically established
early clinical studies
Legal status (DE)
not approved
not approved
WADA-listed
Yes
Yes
Half-life
~25–40 minutes
~10–20 minutes
Studies cited
2
3
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