B7-33 · DOSSIER

B7-33

B7-33 · Single-Chain Relaxin · Peptide · 25 AS
LEGAL DE · NOT APPROVEDEVIDENCE · PRECLINICAL2 STUDIES
FIG.01 — SIGNAL CHAIN
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Mechanism of action

What B7-33 does in the body — step by step.

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B7-33 is a single-chain, simplified mimetic of the hormone relaxin-2.

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Unlike natural two-chain relaxin it is more readily accessible synthetically and is said to act functionally selectively at the relaxin receptor RXFP1: primarily via anti-fibrotic (anti-scarring) signalling, with weaker activation of other cascades.

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It is investigated in preclinical models of organ fibrosis and cardiac injury.

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Research status

How far along is the evidence?

PRECLINICALEARLY CLINICAL STUDIESCLINICALLY ESTABLISHED
B7-33 has so far been studied exclusively preclinically.
B7-33 has so far been studied exclusively preclinically.
Work describes B7-33 as a functionally selective RXFP1 agonist with cardioprotective and anti-fibrotic effects in cell and animal models.
Controlled human studies do not exist.
Safety and efficacy in humans are not demonstrated.
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Known risks

Without human data, safety statements are limited. What is known:

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No human studies — safety profile entirely unknown
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Interference with fibrotic/vascular signalling with unclear consequences
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Interactions not characterised
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Product quality cannot be verified from unapproved sources
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Cited studies

Chronological — links lead to the source.

2016
A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1
PubMed 30155023 →
2023
The single-chain relaxin mimetic, B7-33, maintains the cardioprotective effects of relaxin
PubMed 36753958 →
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Frequently asked questions

What is B7-33?+

B7-33 is a single-chain, simplified mimetic of the hormone relaxin-2.

What type of peptide is B7-33?+

B7-33 belongs to the Other class.

What is B7-33 used for?+

In research, B7-33 has primarily been investigated in the context of: Recovery. These are research findings (evidence: preclinical), not proven benefits in humans and not a usage recommendation.

Is B7-33 legal in Germany?+

B7-33 is not approved as a medicine in Germany. Obtaining it outside clinical studies is legally problematic.

Is B7-33 FDA-approved / legal in the US?+

No. B7-33 is not FDA-approved as a drug in the US; it is mostly sold as a research chemical and not for human consumption.

Is B7-33 legal in Canada?+

No. B7-33 is not authorized by Health Canada and not intended for human consumption.

Where can I buy B7-33?+

Peptica sells nothing and names no sources. B7-33 is "not approved" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.

What is the dosage of B7-33?+

Peptica publishes no dosing. There are no approved dosing guidelines for B7-33; figures circulating online stem from animal studies or anecdote, not from validated human protocols. This is not medical advice.

Is B7-33 banned in sport (WADA)?+

B7-33 is currently not on the WADA Prohibited List.

What are the known risks of B7-33?+

Documented risks include: No human studies — safety profile entirely unknown; Interference with fibrotic/vascular signalling with unclear consequences. This is not a complete safety assessment and not medical advice — see the risks section for the full list.

How well researched is B7-33?+

The evidence is classified as “preclinical”. 2 studies are cited on this page.

Which peptides are related to B7-33?+

Closely related entries: BPC-157, TB-500, ARA 290 (Cibinetid). A direct side-by-side comparison is available via the compare function.

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Dossier

Legal · Structure · Sources.

LEGAL STATUS BY REGION
Germanynot approved

B7-33 is not approved as a medicine and is solely a preclinical research substance. Not on the WADA Prohibited List. Obtaining it as a research chemical carries considerable quality and safety risks.

Legal status varies by country and can change. This is not legal advice.

SOURCES & EXTERNAL DATABASES

Methodology: Peptica compiles publicly available studies and regulatory information and assigns each statement an evidence level. Not medical advice. No warranty.

RELATED PEPTIDES & FURTHER READING
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Community notes

Note: These posts are user opinions and not medical advice. Posts containing dosages, therapeutic claims or purchase recommendations are removed. All entries are manually reviewed before publication.
This page is intended solely for factual, scientifically oriented information. No medical advice · no dosage or usage recommendations · no claims of efficacy · no substitute for medical consultation. Peptica sells no substances. Partner links are marked as advertising; Peptica may earn a commission. © 2026 Peptica · Issue 01