Structure · schematic
Peptide chain of 43 amino acids · Thymosin
Sequence
Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES
Schematic representation of the amino acid chain — not a chemical structural formula. Each node represents one amino acid (shown truncated).
Research areas*
* Contexts in which the peptide has been scientifically studied — not assured or recommended effects.
Mechanism of action
- TB-500 (as a synthetic analog of thymosin beta-4, a naturally occurring peptide) interacts with G-actin and regulates actin polymerisation in cells.
- Thymosin beta-4 is expressed endogenously in high concentrations in platelets and other cells and is involved in cell migration, proliferation and differentiation.
- Preclinical studies suggest interactions with angiogenic and inflammation-modulating signalling pathways.
- The term 'TB-500' is a trade designation for a synthetic fragment analog and is not identical to native thymosin beta-4.
Research status
- Thymosin beta-4 has been investigated in the context of cardiac muscle regeneration after myocardial infarction (preclinical models) as well as wound healing and neuroprotection.
- Clinical studies of thymosin beta-4 (Regentec/RegeneRx) were conducted for eye conditions (dry eye, neurotrophic keratitis), with mixed results.
- For the synthetic TB-500 variant (trade name, research chemical), no published clinical human studies exist.
- Cardiovascular applications are at an early preclinical stage.
Evidence level
Cited studies
Known risks
- 01No controlled human studies of synthetic TB-500 — safety profile not established
- 02Theoretical risk of uncontrolled cell differentiation (growth-factor activity)
- 03Unknown interactions with existing heart conditions
- 04Product quality cannot be verified from unapproved sources
- 05WADA ban: doping-relevant in competitive sport
Frequently asked questions
What is TB-500?
TB-500 (as a synthetic analog of thymosin beta-4, a naturally occurring peptide) interacts with G-actin and regulates actin polymerisation in cells.
What type of peptide is TB-500?
TB-500 belongs to the Thymosin class.
Is TB-500 legal in Germany?
TB-500 is not approved as a medicine in Germany. Obtaining it outside clinical studies is legally problematic.
Where can I buy TB-500?
Peptica sells nothing and names no sources. TB-500 is "not approved" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.
Is TB-500 banned in sport (WADA)?
Yes. TB-500 is on the WADA Prohibited List and is therefore banned in competitive sport.
What are the known risks of TB-500?
Documented risks include: No controlled human studies of synthetic TB-500 — safety profile not established; Theoretical risk of uncontrolled cell differentiation (growth-factor activity). This is not a complete safety assessment and not medical advice — see the risks section for the full list.
How well researched is TB-500?
The evidence is classified as “preclinical”. 3 studies are cited on this page.
What is the molecular weight of TB-500?
TB-500 has a molar mass of about 4963 Da.
Which peptides are related to TB-500?
Closely related entries: BPC-157. A direct side-by-side comparison is available via the compare function.
Related entries
Legal status
Germany
not approvedAustria
not approvedSwitzerland
not approvedEU
not approvedUSA
not approvedCanada
not approvedLegal status varies by country and can change. This is not legal advice.
Sources & methodology
- 3 peer-reviewed studies cited, linked to PubMed where available.
- Molecular data verified against PubChem and primary literature. PubChem CID 45382195
- Editorial standard: no dosage guidance, no sources, evidence level stated explicitly.
Last editorially reviewed: 1 May 2026
Legal assessment
Thymosin beta-4 and TB-500 are on the WADA Prohibited List (section S2). The substance is not approved as a medicine in the EU. Thymosin beta-4 is used in veterinary medicine in some countries (e.g. Australia) for horses; these approvals do not apply to human use. Legal status on import is unclear — conservative assessment: not to be obtained.
Important notice
This site is intended solely for factual, scientifically oriented information about peptides. It does not constitute medical advice, does not replace a consultation with a doctor and contains no recommendations for use in humans.
This site does not sell any substances and names no sources for unapproved substances. For medical questions, please consult qualified medical professionals.
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