TB-500
In preclinical models it promoted cell migration and tissue repair in muscle, heart and wounds.
What it does in the body
Findings, each with its evidence level — animal data kept visibly apart from what's unproven in humans.
In preclinical models it promoted cell migration and tissue repair in muscle, heart and wounds.
ANIMAL MODELS ONLYSteers the cell-scaffold protein actin, thereby influencing blood-vessel formation and inflammation.
MECHANISM ONLYThymosin β4 has been studied for cardiac-muscle regeneration after heart attack — so far only preclinical.
ANIMAL MODELS ONLYNo published human studies exist for synthetic TB-500; eye studies with thymosin β4 had mixed results.
UNPROVEN IN HUMANSMechanism of action
What TB-500 does in the body — step by step.
TB-500 (as a synthetic analog of thymosin beta-4, a naturally occurring peptide) interacts with G-actin and regulates actin polymerisation in cells.
Thymosin beta-4 is expressed endogenously in high concentrations in platelets and other cells and is involved in cell migration, proliferation and differentiation.
Preclinical studies suggest interactions with angiogenic and inflammation-modulating signalling pathways.
Research status
How far along is the evidence?
Known risks
Without human data, safety statements are limited. What is known:
Cited studies
Chronological — links lead to the source.
Frequently asked questions
What is TB-500?+
TB-500 (as a synthetic analog of thymosin beta-4, a naturally occurring peptide) interacts with G-actin and regulates actin polymerisation in cells.
What type of peptide is TB-500?+
TB-500 belongs to the Thymosin class.
What is TB-500 used for?+
In research, TB-500 has primarily been investigated in the context of: Recovery, Muscle growth, Immunomodulation. These are research findings (evidence: preclinical), not proven benefits in humans and not a usage recommendation.
Is TB-500 legal in Germany?+
TB-500 is not approved as a medicine in Germany. Obtaining it outside clinical studies is legally problematic.
Is TB-500 FDA-approved / legal in the US?+
No. TB-500 is not FDA-approved as a drug in the US; it is mostly sold as a research chemical and not for human consumption.
Is TB-500 legal in Canada?+
No. TB-500 is not authorized by Health Canada and not intended for human consumption.
Where can I buy TB-500?+
Peptica sells nothing and names no sources. TB-500 is "not approved" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.
What is the dosage of TB-500?+
Peptica publishes no dosing. There are no approved dosing guidelines for TB-500; figures circulating online stem from animal studies or anecdote, not from validated human protocols. This is not medical advice.
Is TB-500 banned in sport (WADA)?+
Yes. TB-500 is on the WADA Prohibited List and is therefore banned in competitive sport.
What are the known risks of TB-500?+
Documented risks include: No controlled human studies of synthetic TB-500 — safety profile not established; Theoretical risk of uncontrolled cell differentiation (growth-factor activity). This is not a complete safety assessment and not medical advice — see the risks section for the full list.
How well researched is TB-500?+
The evidence is classified as “preclinical”. 3 studies are cited on this page.
What is the molecular weight of TB-500?+
TB-500 has a molar mass of about 4963 Da.
Which peptides are related to TB-500?+
Closely related entries: BPC-157. A direct side-by-side comparison is available via the compare function.
Dossier
Legal · Structure · Sources.
Thymosin beta-4 and TB-500 are on the WADA Prohibited List (section S2). The substance is not approved as a medicine in the EU. Thymosin beta-4 is used in veterinary medicine in some countries (e.g. Australia) for horses; these approvals do not apply to human use. Legal status on import is unclear — conservative assessment: not to be obtained.
Legal status varies by country and can change. This is not legal advice.
Methodology: Peptica compiles publicly available studies and regulatory information and assigns each statement an evidence level. Not medical advice. No warranty.