Structure · schematic
Peptide chain of 34 amino acids · PTH-Analog
Schematic representation of the amino acid chain — not a chemical structural formula. Each node represents one amino acid (shown truncated).
Research areas*
* Contexts in which the peptide has been scientifically studied — not assured or recommended effects.
Mechanism of action
- Abaloparatide is a synthetic analog of parathyroid hormone-related peptide (PTHrP 1-34).
- It binds preferentially to the RG conformation of the PTH-1 receptor, which is thought to produce a more anabolically oriented, more transient signalling response than teriparatide.
- Like teriparatide it is used intermittently (once daily) to favour bone formation over resorption.
Research status
- Abaloparatide is approved as an osteoporosis medicine.
- The pivotal ACTIVE trial (Miller et al., 2016) showed a significant reduction in new vertebral and non-vertebral fractures versus placebo in postmenopausal women.
- The ACTIVExtend follow-up investigated sequential alendronate after abaloparatide.
- As with teriparatide, treatment duration is limited because of preclinical osteosarcoma signals.
Evidence level
Cited studies
Known risks
- 01Hypercalcaemia and hypercalciuria possible
- 02Orthostatic hypotension, dizziness, palpitations
- 03Nausea and headache described in studies
- 04Osteosarcoma signal in animal models — treatment duration limited
- 05Contraindicated with increased osteosarcoma risk and bone malignancy
Frequently asked questions
What is Abaloparatid?
Abaloparatide is a synthetic analog of parathyroid hormone-related peptide (PTHrP 1-34).
What type of peptide is Abaloparatid?
Abaloparatid belongs to the PTH analog class.
Is Abaloparatid legal in Germany?
Abaloparatid is prescription-only in Germany and may only be obtained with a medical prescription.
Where can I buy Abaloparatid?
Peptica sells nothing and names no sources. Abaloparatid is "prescription-only" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.
Is Abaloparatid banned in sport (WADA)?
Abaloparatid is currently not on the WADA Prohibited List.
What are the known risks of Abaloparatid?
Documented risks include: Hypercalcaemia and hypercalciuria possible; Orthostatic hypotension, dizziness, palpitations. This is not a complete safety assessment and not medical advice — see the risks section for the full list.
How well researched is Abaloparatid?
The evidence is classified as “clinically established”. 2 studies are cited on this page.
What is the molecular weight of Abaloparatid?
Abaloparatid has a molar mass of about 3960.6 Da, with a plasma half-life of ~1 hour (s.c.).
Which peptides are related to Abaloparatid?
Closely related entries: Teriparatid. A direct side-by-side comparison is available via the compare function.
Related entries
Legal status
Germany
prescription-onlyAustria
prescription-onlySwitzerland
prescription-onlyEU
approved medicineUSA
prescription-onlyCanada
not approvedLegal status varies by country and can change. This is not legal advice.
Sources & methodology
- 2 peer-reviewed studies cited, linked to PubMed where available.
- Molecular data verified against PubChem and primary literature. PubChem CID 76943386
- Editorial standard: no dosage guidance, no sources, evidence level stated explicitly.
Last editorially reviewed: 30 May 2026
Important notice
This site is intended solely for factual, scientifically oriented information about peptides. It does not constitute medical advice, does not replace a consultation with a doctor and contains no recommendations for use in humans.
This site does not sell any substances and names no sources for unapproved substances. For medical questions, please consult qualified medical professionals.
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