Thymuspeptid

Thymosin Alpha-1

Tα1

Thymosin alpha-1 (Tα1) is a 28-amino-acid peptide originally isolated as fraction 5 from the thymus. It is a natural cleavage product of prothymosin alpha and is produced mainly in thymic epithelial cells. Tα1 modulates T-cell maturation and function: it promotes the Th1 response, increases the activity of natural killer cells (NK cells) and stimulates the production of IL-2, interferon-gamma and interferon-alpha. Its molecular site of action includes Toll-like receptors (TLR2 and TLR9) on dendritic cells, which explains its activation of the adaptive immune response.