Substance class
PTH-Analog
2 entries
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Teriparatid
Teriparatide
Teriparatide is the recombinant N-terminal fragment (1-34) of human parathyroid hormone (PTH). It binds to the PTH-1 receptor on osteoblasts and osteocytes. Unlike a persistently elevated PTH concentration (which promotes bone resorption), intermittent once-daily administration produces a predominantly anabolic effect on bone. A stimulation of osteoblast activity and an increase in bone mass and structure have been described.
Abaloparatid
Abaloparatide
Abaloparatide is a synthetic analog of parathyroid hormone-related peptide (PTHrP 1-34). It binds preferentially to the RG conformation of the PTH-1 receptor, which is thought to produce a more anabolically oriented, more transient signalling response than teriparatide. Like teriparatide it is used intermittently (once daily) to favour bone formation over resorption.