Direct comparison
IGF-1 vs IGF-1 LR3
Class
IGF / insulin analog
IGF / insulin analog
Mechanism
IGF-1 is a 70-amino-acid polypeptide with structural homology to insulin.
IGF-1 LR3 is a synthetically modified variant of human IGF-1.
Studied effects
Muscle growth, Recovery
Muscle growth
Evidence level
early clinical studies
preclinical
Legal status (DE)
prescription-only
not approved
WADA-listed
Yes
Yes
Half-life
~12–15 hours (protein-bound)
Markedly extended: ~20–30 hours, because the Arg³ substitution and N-terminal extension sharply reduce binding to IGF-binding proteins (native IGF-1: ~12–15 h).
Studies cited
3
2
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