KPV
Mechanism of action
What KPV does in the body — step by step.
KPV is a tripeptide (lysine-proline-valine) corresponding to the C-terminal end of α-melanocyte-stimulating hormone (α-MSH).
While the full α-MSH (13 amino acids) is strongly pigmenting and binds MC1R/MC3R, the KPV fragment exerts its anti-inflammatory effects via mechanisms that are partly independent of melanocortin receptors.
KPV inhibits NF-κB signalling pathways in intestinal epithelial cells and immune cells, reduces the release of pro-inflammatory cytokines (IL-8, TNF-α) and appears able to enter inflammatory cells directly.
Research status
How far along is the evidence?
Known risks
Without human data, safety statements are limited. What is known:
Cited studies
Chronological — links lead to the source.
Frequently asked questions
What is KPV?+
KPV is a tripeptide (lysine-proline-valine) corresponding to the C-terminal end of α-melanocyte-stimulating hormone (α-MSH).
What type of peptide is KPV?+
KPV belongs to the MSH fragment class.
What is KPV used for?+
In research, KPV has primarily been investigated in the context of: Immunomodulation, Skin & hair. These are research findings (evidence: preclinical), not proven benefits in humans and not a usage recommendation.
Is KPV legal in Germany?+
The regulatory status of KPV in Germany is not clearly classified.
Is KPV FDA-approved / legal in the US?+
No. KPV is not FDA-approved as a drug in the US; it is mostly sold as a research chemical and not for human consumption.
Is KPV legal in Canada?+
No. KPV is not authorized by Health Canada and not intended for human consumption.
Where can I buy KPV?+
Peptica sells nothing and names no sources. KPV is "unclassified" in Germany; obtaining unapproved substances outside clinical studies is illegal and carries quality and safety risks.
What is the dosage of KPV?+
Peptica publishes no dosing. There are no approved dosing guidelines for KPV; figures circulating online stem from animal studies or anecdote, not from validated human protocols. This is not medical advice.
Is KPV banned in sport (WADA)?+
KPV is currently not on the WADA Prohibited List.
What are the known risks of KPV?+
Documented risks include: No clinical safety data in humans; Long-term effects entirely unknown. This is not a complete safety assessment and not medical advice — see the risks section for the full list.
How well researched is KPV?+
The evidence is classified as “preclinical”. 3 studies are cited on this page.
What is the molecular weight of KPV?+
KPV has a molar mass of about 342.43 Da.
Which peptides are related to KPV?+
Closely related entries: BPC-157, LL-37. A direct side-by-side comparison is available via the compare function.
Dossier
Legal · Structure · Sources.
KPV is not an approved medicine and has no regulated status in the EU. Not on the WADA Prohibited List. In the absence of clinical studies, a sound risk-benefit assessment is not possible.
Legal status varies by country and can change. This is not legal advice.
Methodology: Peptica compiles publicly available studies and regulatory information and assigns each statement an evidence level. Not medical advice. No warranty.